Arizona Cardinals vs. Dallas Cowboys MNF Prediction (November 3, 2025)
The Dallas Cowboys (3-4-1) are favored to get back to .500 on Monday Night Football this week, as they close out week 9 as 3-point home favorites against the Arizona Cardinals.
It’s been an up and down campaign for Dak Prescott and co., but Dallas continues to offer a solid offensive ceiling, and holds their fate in their own hands. The same probably isn’t true for Arizona, who have a tough task in trying to steal a road win in a hostile environment without star quarterback Kyler Murray leading the charge.
Instead, it will be Jacoby Brissett trying to stage the upset, as Arizona enters as a +145 underdog. The game itself could still be highly entertaining, of course, as fans and bettors can take in a contest with a healthy 54.5 game total.
Unsure of who to bet on in this game? I’ll take a look at the latest Cardinals vs. Cowboys odds, scan the matchups, and gauge which bets are worth targeting ahead of MNF.
Game Info Snapshot
- Date & Location: Monday, November 3rd, 2025 | Kickoff at 7:15 pm ET (ESPN) at AT&T Stadium in Arlington, TX
- Team records entering the game:
- Cardinals: 2-5
- Cowboys: 3-4-1
- Odds (from DraftKings)
- Spread: Cardinals +3.5 (-115) | Cowboys -3.5 (-105)
- Moneyline: Cardinals (+150) | Cowboys (-180)
- Total: Over 53.5 (-110) | Under 53.5 (-110)
Dallas is priced as the clear favorite at home. The line is still surprisingly tight, which suggests the oddsmakers don’t exactly trust an erratic Dallas team, and/or that the Cardinals could have a chance at the upset. The 54.5 game total hints at the Cowboys’ explosive offense and two suspect defenses in a dome.
Storylines to Watch
The big story to watch is the absence of Kyler Murray. Arizona has struggled mightily on the year, as they are winless since a 2-0 start. However, not having their franchise passer puts them behind the 8-ball, and they’ll turn to journeyman passer Jacoby Brissett to help them snap their five-game losing streak.
See what other storylines stand out for this MNF tilt:
- Competitive Play: Arizona has lost five straight games, and they are going to war with their backup QB, but they’ve still been competitive. During this five-game skid, they haven’t gotten blown out once, and they’ve scored 20+ points four times. A competitive game really isn’t a crazy expectation.
- MHJ Breakout Uploading: Marvin Harrison Jr. is immensely talented, so it really is only a matter of time before he drops a nuke in an NFL game. In a game with a 54.5 total and given how bad this Dallas pass defense is, this could be the game where he shows out.
- Dak Attack: While the Arizona offense could shine here, this game is all about Dak Prescott once again putting the Cowboys on his back. At 3-4-1, a home loss to a reeling Cardinals team wouldn’t just be a bummer, it’d be a season killer. Dak needs to show up in a big way and make sure Dallas gets back to .500.
- Send a Message: How about the Dallas D finally sending a message? At home, under the bright lights of MNF, and facing a backup QB, what better time is there for a weak defense to rise up and be the reason for their team’s success?
Team Profiles
Arizona Cardinals
The Arizona Cardinals were a surprising 2-0 team through the NFL’s first two weeks, but they fell hard back to reality and come into week 9 at just 2-5. To their credit, they’ve navigated some key injuries – namely, to Kyler Murray – and have remained extremely competitive.
Their record stinks, but the Cards are doing a few things well in 2025:
- Competitive Streak: Arizona is far from perfect, but they (seriously) could be undefeated right now if things went a different way. They have lost their last five games by a combined 13 points.
- Bright Spot: While his play hasn’t translated to victories yet, Jacoby Brissett has been on point in relief of Murray. He’s completing over 64% of his passes for four touchdowns and just one interception.
- Ground Control: The Cardinals have been solid against the run. That might be bad news for Javonte Williams, seeing as they rank 12th in rush defense and 14th in yards per rush allowed.
Dallas Cowboys
The Dallas Cowboys impressed with a tight loss to the defending Super Bowl champion Eagles in week one, and then lit up the scoreboard in a 40-37 win over the Giants in week two.
They’ve been pretty inconsistent ever since, though, as they had a 40-40 tie with the Packers, and have either crushed their opponent or got tripped up by seemingly inferior competition in other contests.
Through it all, the Cowboys are still dripping with talent and offensive upside. Here’s a quick look at where they stand out the most:
- Not Washed: Javonte Williams was an odd signing this offseason, as many felt the former Broncos RB was washed. That hasn’t been the case, though, as he’s pieced together a Comeback Player of the Year campaign with 633 rushing yards and 8 TDs at a 5.1 clip – all contributing to the league’s 13th best ground game.
- Potent O: Javonte Williams is a big piece to the puzzle in Big D, but their offense as a whole is the reason they win any game. Dak Prescott spearheads the league’s best passing game, while the Cowboys are pouring in the 2nd most points (30.8) per game on the year.
- Secret Weapon: An extension of that killer Cowboys offense is kicker Brandon Aubrey, who nailed a 65-yarder in a game this year and paces all of football with a perfect conversion rate so far in 2025. Considering how close Arizona seems to play everyone, he could very well be the deciding factor in this matchup.
Key Matchups & Angles
Take a look at the key Cardinals vs. Cowboys matchups for MNF:
- Jacoby Brissett vs. Dallas secondary: You would think this could be a spot where the Cowboys’ defense could have a chance to shine. But hey, Jacoby has been great, and Dallas ranks 31st against the pass.
- Can Dallas Stifle Trey McBride?: We know MHJ has a chance to go off in this matchup, but the bigger question is if tight end Trey McBride can have a big impact. Dallas has been solid against the position in 2025, but they haven’t gone up against many TEs of his caliber.
- Dallas rush offense vs. Arizona run defense: This may actually be the key to the game. Dallas relies on their passing game a ton, but they still need Javonte and the ground game to be successful. That is far from a given against a solid Cardinals front seven.
- Dak Prescott vs. Arizona pass rush: The Cardinals have the 28th-ranked sack rate in the NFL. It’s fairly likely that it doesn’t improve dramatically in a road setting like this. If Dak has all day to throw, he could tee off on this Arizona defense (25th vs. pass).
Betting Trends & Odds Context
Check out the latest odds, per DraftKings:
| Team | Spread | Moneyline | Total |
|---|---|---|---|
Cardinals | +3.5 (-115) | +150 | Over 53.5 (-110) |
Cowboys | -3.5 (-105) | -180 | Under 53.5 (-110) |
Take a look at some key betting trends for this MNF tilt:
- Public Betting: Everyone sees Dallas winning this thing, as 93% of the bets and 95% of the money are on the Cowboys right now.
- Matchup History: These teams used to both play in the NFC East and have met an astonishing 92 times. Dallas holds a huge 56-35-1 series lead, but has oddly enough lost each of the last three meetings.
- ATS Data: The Cardinals have been super competitive all season, which has allowed them to be a decent 4-3 ATS despite a 2-5 record. They’re also 3-2 against the spread in non-division games and 2-0 ATS as the road underdog. Dallas has been OK, too, going 4-4 ATS overall and 1-1 against the spread as the home favorite.
Best Bets for Cardinals vs. Cowboys
Pick 1: Cowboys ML (-175) – 9/10 Confidence
Why We Like It
The Cowboys are at home against an inferior team that may be ready to give in. Arizona has also lost five games in a row, and without Kyle Murray, probably won’t be able to keep up with Dallas.
Risks/What to Watch
Believe it or not, Jacoby Brissett has actually been pretty good. Arizona’s record is bad, but they’ve been in literally every single one of their losses – all one-score games. Given the Cowboys’ weak defense, a close game (and an upset) isn’t impossible.
Pick 2: Prop Play – Javonte Williams Anytime TD (-165) – 7/10 Confidence
Why We Like It
Dallas may pass at an obscene 60% rate, but they don’t mind running when they get close to the goal-line. That’s led to the league’s 11th-best red-zone offense and Javonte Williams punching in nine total touchdowns. He’s a good bet to hit paydirt against Arizona, who allows 0.7 rushing scores (20th) per contest.
Risks/What to Watch
Arizona’s defense is at its best against the run, and Dallas throws a ton. The Cardinals could shut Javonte out of the end-zone, or the Cowboys scoring could just as easily come through the air.
Pick 3: Over 54.5 Total (-110) – 7/10 Confidence
Why We Like It
Dallas is very likely to account for a bunch of these points all on their own, as they have topped 37+ points four different times this year. Arizona is plenty capable, too, while the matchup with Dallas (2nd most points allowed per game) is about as good as it gets.
Risks/What to Watch
Arizona could easily lose their fire, and with Jacoby Brissett set to flame out, the offense could hit a wall on the road.
Arizona Cardinals vs. Dallas Cowboys odds can shift fast — stay ahead of line changes and compare spreads now at our top football betting sites before kickoff.
Final Verdict: Cowboys Get Back to .500
Final Score Prediction: Cowboys 34, Cardinals 24
Arizona may be able to put up a fight in this one, but I don’t think it will be enough to win. Dallas tends to be very hard to beat at Jerry World (2-0 there so far this year), and unless the defense they’re facing is elite, there’s a good chance they’re hanging 30+ points on it.
I expect even more than that out of Big D on Monday Night Football, with the only question being if Arizona can keep up. The matchup should allow them to do it for long enough, so we can comfortably hammer the Over and Dallas to cover.
The safest bet is the Cowboys ML, though, as they are simply the better team and they badly need a win here to keep their playoff hopes alive.
