Arizona State vs. Colorado Prediction & Top Betting Picks (November 22, 2025)
The Colorado Buffaloes will hope to finish a disappointing season strong down the stretch, but they won’t be favored to get a win on Saturday (+240 underdogs) against the Arizona State Sun Devils.
It’s been a trying season for Deion Sanders’ crew, as year one without the likes of Shedeur Sanders and Travis Hunter has resulted in a rough 3-7 mark. The Buffaloes will be at home, but they look overmatched on paper and have also gone just 3-3 on their home field.
Arizona State enters Saturday as 7.5-point favorites, which is fairly telling since they’ll be on the road. The Sun Devils are in solid form, however, and technically still have a shot at winning the Big 12 title.
This matchup looks fairly straightforward on paper, but I’ll look through the latest odds for any edge we can find. Along the way I’ll point to the best bets for this contest, as well as my ultimate Arizona State vs. Colorado prediction.
Game Basics & Context
- Matchup: Arizona State Sun Devils (7-3) vs. Colorado Buffaloes (3-7)
- Date & Time: Saturday, November 22nd, with kickoff at 7:00 pm CT (8:00 pm ET)
- Venue: Folsom Field in Boulder, CO
- How to Watch: The game will be broadcast on ESPN2
Team Record
- Arizona State is 7-3, 5-2 in the Big 12.
- Colorado is 3-7, 1-6 in the Big 12.
Betting Odds
Check out the latest Arizona State vs. Colorado odds, per FanDuel:
| Team | Spread | Moneyline | Total |
|---|---|---|---|
Arizona State | -7.5 (+104) | -255 | Over 46.5 (-114) |
Colorado | +7.5 (-128) | +215 | Under 46.5 (-106) |
Rivalry & Venue Context
This is not a very storied rivalry, as the Sun Devils and Buffaloes have only faced off 13 times before. It’s been mostly Arizona State, as they lead the all-time series, 9-4.
Colorado did steal a win in the most recent meeting, of course, winning a tight 27-24 shootout back in 2023. Arizona State won the game before that (42-34), giving bettors a look at what has historically been a competitive matchup with some good scoring.
The Buffaloes lost the most recent meeting in this series at their home field and are just 3-3 here on the season.
Why This Game Matters
This game is meaningless for Colorado, short of trying to end the year on a high note and give their hometown fans a win. They’re out of bowl contention and have nothing but pride to play for.
Rivalry games technically can always mean something, but this game is actually a big deal for Arizona State. They are 5-2 in the Big 12 and technically could still win the conference title. That’s probably a pipedream, but a bowl game certainly is not.
Team Profiles
Arizona State Sun Devils
The Sun Devils are not exactly elite on offense, but they are quite steady. They got off to a nice 1-0 start by dropping 38 points in week one, but that would be the most points they score in a game all year.
Each of their losses are pretty reasonable, as they lost by four to Mississippi State in week two and fell by eight to Houston a few weeks ago. Their only other loss was a 42-10 blowout, but came against a good Utah squad.
Overall, the Sun Devils are very competitive and balanced and boast a defense good enough to keep them in most games. Here’s a quick look at where they stood out the most this year:
- Ground Control: The Sun Devils rack up the yardage on the ground, putting up over 179 rushing yards per game (35th). That’s even more impressive when you consider they’re not even inside the top-50 in rush rate.
- Bubble Wrap: Along with a balanced offense, Arizona State is elite at avoiding negative plays. They rank 6th in sack rate allowed and are also committing the 12th fewest turnovers in all of college football.
- Sniff it Out: On the other side of the ball, the Sun Devils have a really strong run defense that allows just 3.5 yards per carry (27th) and plays into a suffocating red-zone unit that does not buckle (26th) very often.
Colorado Buffaloes
The Buffaloes obviously lost some star talent to the NFL Draft over the offseason, and they’ve struggled to effectively replace that production and continuity.
Unfortunately, this just hasn’t been a very good team. The offense lacks explosiveness or consistency, while the defense allows 30 points per game (96th).
At 3-7, it doesn’t take much to see that hasn’t translated into a great year. They do get credit for only losing to Georgia Tech by seven back in week one, while they have yet to fully mail it in (lost 29-22 to West Virginia last game).
It’s been ugly, but here are a few spots the Buffaloes have stood out:
- Down the Field: Colorado wants to be good at running the football (52% rush rate), but they’ve been inefficient. They’ve been passable (7.2 yards per play) through the air, however.
- Containment: There isn’t much to get excited about the Buffaloes on defense, but they at least have limited opposing passing attacks to a certain degree (49th against the pass).
- Opportunistic: When things have gone right, Colorado tends to pop up with a big play on defense. They’re not elite at it by any means, but they force 1.2 turnovers per game (78th) and it can help them stay competitive.
Key Matchup Angles
Consider the following key Colorado vs. Arizona State matchups:
- Arizona State’s rushing offense vs. Colorado’s run defense: The obvious key to this contest is the Sun Devils’ ground game. Running back Raleek Brown (823 rushing yards) leads this offense into a soft matchup, as Colorado allows a staggering 210.9 rushing yards per game (129th!).
- Colorado’s RZ offense vs. Arizona State’s RZ defense: The Sun Devils only allow a red-zone score 78% of the time. Colorado is actually very good (28th) at finishing drives when in scoring position.
- Arizona State’s o-line vs. Colorado’s pass rush: It doesn’t stand out as a strength for the Buffaloes (112th in sack rate), but if they can exploit a shaky Arizona State offensive line (110th in sack rate allowed), they could have an edge.
Betting Insights & Trends
Arizona State has a nice record, but they’ve been weak (4-5-1) against the spread. The Sun Devils are just 1-4-1 ATS when favored, and they’re just 2-2 against the spread on the road.
Colorado is as bad against the spread as they are at actually winning games. They’re 3-6-1 ATS overall, while they are 2-5 against the spread inside the Big 12 and 2-6 ATS as the underdog.
Arizona State is trending in a positive direction, winning two straight and three of their last four. Colorado is going the other way, as they have lost three in a row and five of the last six.
Best Bets & Confidence Levels
Check out my top Arizona State vs. Colorado picks:
| Bet | Recommendation | Confidence Level |
|---|---|---|
Arizona State ATS -7.5 (+104) | The Sun Devils aren’t great ATS, but I think they cover here. Colorado is dead in the water, and this is a total mismatch. Arizona State should be able to run at will, and Colorado’s defense is pathetic. | 7/10 |
Over 46.5 (-114) | Arizona State’s offense isn’t elite, but they have a clear matchup edge against a bad defense that allows 30 points regularly. Colorado should be able to do enough to contribute to the Over. | 7/10 |
Prop Play – Raleek Brown Over 70+ Rushing Yards (-146) | Brown hasn’t topped this mark since in any of his last five games, but he’s come awfully close. We know he has upside as a rusher, and the matchup is as good as it gets. | 7/10 |
- Primary Pick: Arizona State ATS -7.5 (+104)
- Secondary Pick: Over 46.5 (-114)
Big 12 games can be tough to gauge, and this spread is a tad ambitious. However, Arizona State has the edge on both sides of the ball and has an incentive to take care of business while leaving no doubt.
Colorado’s offense should be able to do just enough to combine with their horrific defense to get total bettors where they need to go.
While Raleek Brown hasn’t converted this exact rushing yardage total in a bit, he does have three 100+ yard rushing days to his name in 2025. In this spot, I would honestly be comfortable doing a ladder bet with him. If you want to play it safer, hammer him at 60+ for -215 at FanDuel.
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Risk Factors & What Could Go Wrong
Things don’t always go as planned when betting on college football. Here’s why my Arizona State vs. Colorado bets could fail:
- Rivalry Setting: These two teams do know each other and have played each other pretty well in the last two meetings. That’s enough to potentially mess with my ATS pick.
- Nothing to Lose: Colorado could mess with my picks if they decide to play spoiler. They did put up a fight in their last game, after all.
- Defensive Battle: I think the Sun Devils dominate on the ground and run up the score, but they have topped this total just once in their last four games. A lower-scoring game isn’t out of the question.
Putting Our Pick on the Board: Here’s How It Plays Out
Final Score Prediction: Arizona State 30, Colorado 17
The Buffaloes will do just enough to get us to the Over. They’re at home and showed last week they still have some fight, so I’ll give them some credit.
However, the Buffaloes are possibly missing some key defenders and may even be without some starters on the o-line. They were already looking at a mismatch, but if some of their main guys end up sitting, this thing tilts way further toward the Sun Devils.
Arizona State can win this game from anywhere on the field, but the spot they’ll dominate is in the trenches and on the ground. I think that gets them the win, has them cover, and gives us a decent scoring output. If that all works out – and maybe even if it doesn’t – the matchup is so good that Raleek Brown can hit this rushing yardage prop in his sleep.
