Detroit Lions vs. Philadelphia Eagles Prediction & Top Bets (November 16, 2025)
The best NFL game of the week is saved for Sunday Night Football, where the visiting Detroit Lions will be mild +126 underdogs against the Philadelphia Eagles.
Both teams are fighting for first place in the NFC, and a win here for Philly would put them in sole possession of first place thanks to a tiebreaker win over the Los Angeles Rams.
Naturally, this is a huge game for the Lions, who need to win to keep themselves in the running for that top spot. The moneyline and point spread (+2.5) indicate it will be a close game, while the 46.5 game total sets fans and sports bettors alike up for a bit of a slugfest.
Will the Lions come into Philadelphia and get the win, or will the Eagles stand firm and continue their reign atop the NFC? I’ll offer my Lions vs. Eagles predictions, while also touching on the latest odds, key matchups, and my favorite bets for the game.
Game Info Snapshot
- Matchup: Detroit Lions (6-3) vs. Philadelphia Eagles (7-2)
- Date & Time: Sunday, November 16th, 2025 | Kickoff at 7:20 pm ET
- Venue: Lincoln Financial Field in Philadelphia, PA
- How to Watch: NBC/Peacock
The pricing is pretty tight, as oddsmakers anticipate a close game. The 2.5-point spread and +126 moneyline suggest a virtual pick’em.
The game total is straight down the middle. The Eagles are coming off of a game that featured just 17 total points, but both teams have high offensive ceilings.
Storylines to Watch
The biggest storyline is simply what is at stake in this game. The Lions need to win to stay ahead of the pack in the competitive NFC North, while a loss here would drop them out of the #1 seed conversation in the NFC.
As for Philly, the NFC East is already basically wrapped up. However, they can continue to distance themselves from a good chunk of teams when it comes to a potential first round bye.
Here are a few more Lions vs. Eagles storylines to consider:
- Diva WR: Stop me if you’ve heard this before, but Eagles wide receiver A.J. Brown is unhappy with his role and he’s letting everyone hear about it. Whether or not the Eagles fold and feed him the ball – and how that impacts this game – will be interesting to monitor.
- NFC Title Game Preview: This is the NFC Championship game we should have seen last year, but Detroit got upset by the Commanders. This should give us a pretty intense taste of what we could see later in the year at even higher stakes.
- Take Over: Dan Campbell seized control of Detroit’s offensive playcalling, and it worked out beautifully last week. That was just one game, though. How will that move look against a Philly defense that held the Packers to one score?
Team Profiles
Detroit Lions
The Detroit Lions got off to a slow start this year, as they got embarrassed in a week one blowout loss to the Packers. They’ve rebounded nicely since then, going 6-2 ever since.
Detroit entered the season with question marks on both sides of the ball, but the offense hasn’t missed a beat. They’ve topped at least 24+ points in seven of their 10 games, and they come into this SNF tilt with the #2 scoring offense in all of football.
The Lions have reasonable bite on defense, too, as they rank 13th in scoring and are doing a fantastic job limiting big plays.
Here are a few more things that stand out for Detroit going into this matchup:
- TNT: The Lions are as explosive as they come on offense. They are generating the 4th best yards per play average in the NFL (6.1), ranking inside the top-10 in big play rate both on the ground and through the air.
- Mid Protection: While they spring big plays with regularity, the Lions are not elite in pass protection right now. They’re not awful (13th), but this could be a problem against a talented Eagles pass rush.
- Hyper Accurate: Detroit can burn you from anywhere on the field, but they are also painfully accurate. As in, the most accurate passing attack (73.55%) in all of football.
Philadelphia Eagles
The Eagles continue to be an extremely well balanced and gritty team. They get knocked at times for suspect in-game decisions and an ugly playing style, but all they do is win.
Philly comes in with an extremely capable offense and a top-10 scoring defense. They aren’t necessarily better than the Lions at several key areas, but overall they are good enough to match wits with anyone.
Here are a few more key factors for them going into this game:
- Splash Plays: Due to an inefficient rushing game, the Eagles are probably going to need to flip field position with big plays. Fortunately for them, they rank 8th in yards per pass and have the weapons to attack deep down the field.
- Ball Control: Philly’s system and ability to protect the ball make them tough to beat. Jalen Hurts paces all of football (1 INT) in interception percentage, but he could be challenged against a feisty Lions defense (10th in takeaways).
- Finish the Job: Detroit has a great pass rush and can force turnovers, but if the Eagles get near the goal-line, it’s game over. Philly owns the very best red-zone offense (80.95%) in the NFL.
Key Matchups & Angles
Check out the key Lions vs. Eagles matchups:
- Overly Aggressive: Detroit is not shy about being aggressive and given their talent and coaching, they’re often successful at it. They rank 7th in 4th down conversion, which could be a huge deal against a Philly defense that has been even better (5th) at stopping teams on 4th down.
- Long Distance: A massive key to this game for the Lions is to make sure Philly has long third downs. That will slowly remove their ground game and also curb the impact of the famed Tush Push. Owning the league’s 4th best pass rush could be their ticket to leveling the playing field.
- Pound the Rock: The Eagles want to run the ball (3rd in rush rate) as much as anyone. They haven’t been particularly great at it (21st), while the Lions (8th) have stopped the run pretty well on the year.
Betting Trends & Odds Context
Check out the latest Lions vs. Eagles odds, per FanDuel:
| Team | Spread | Moneyline | Total |
|---|---|---|---|
Lions | +2.5 (-104) | +124 | O 46.5 (-114) |
Eagles | -2.5 (-118) | -146 | U 46.5 (-106) |
Take a look at some key betting trends for this showdown:
- Public Betting: This one is wonky, as the Lions are only getting 36% of the bets, but 97% of the money. Expect the money to dip but it’s still a telling stat.
- Record History: These two sides have met 36 times throughout NFL history, with Philly owning an 18-16-2 edge. We haven’t seen a game between these two teams since 2022, but it was a wild 38-35 shootout that the Eagles won.
- ATS Tidbits: Both teams have been pretty good against the spread (6-3), but the Eagles are just 2-2 ATS as the home favorite. They are 5-3 against the spread as favorites in general, though, while they are 5-1 ATS outside of the NFC East. Detroit is 5-1 ATS outside of their division, but just 1-2 against the spread as the underdog.
Best Bets for Lions vs. Eagles
Pick 1: Lions ML (+126) – 7/10 Confidence
Why We Like It
Detroit is the more explosive team and they have key stats that stand out more in this matchup. They can run and pass at elite levels, while they also stop the run well and get after the quarterback. If they play up to their ability, they feel like a screaming value.
Risks/What to Watch
Philly is at home at night in a primetime setting and their ugly style of play usually allows them to dictate the pace of the game. If they can establish the run and keep the game low-scoring, they’ll have the edge.
Pick 2: Over 46.5 (-102) – 7/10 Confidence
Why We Like It
Given Detroit’s offensive upside, I think the Over is the more appealing play. Philly is coming off a season-worst offensive performance, so they’re in for a mild bounce-back on their own.
Risks/What to Watch
Philly’s style leads to a lot of Unders, so if they grind the clock out and limit possessions, this could be an insufferable bet to lose.
Pick 3: Prop Play – A.J. Brown Over 50+ Receiving Yards (-192) – 7/10 Confidence
Why We Like It
This is not a very high yardage total and A.J. Brown is fully capable of getting it in one play. On top of that, Detroit’s pass defense is weaker than their run defense and Brown has publicly griped about not being involved enough in Philly’s offense.
Risks/What to Watch
The Eagles could always choose not to bend the knee and opt not to force the ball to their disgruntled star. That, or the Lions could focus on stopping him just because of how explosive he can be.
Final Verdict: Lions Prove They’re The Team to Beat
Coming to a Lions vs. Eagles prediction isn’t easy, just because there are so many different things to consider. On one hand, the Eagles just flexed their defensive capacity last week and their playing style allows them to control games.
On the other hand, the Lions are a much more dynamic and explosive team on offense, they have the run defense to stifle a struggling Eagles offense, and they also need this game more.
The game should be close, but Detroit is aggressive and will attack all night – something the Packers really didn’t do a week ago. That will lead to the Over and a (narrow) Lions win.
Final Score Prediction: Detroit Lions 27, Eagles 23
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